The Yukon-Kuskokwim Delta is rich in Eskimo culture. Bethel's Yup'ik Cultural Center features museum exhibits, demonstrations of dancing and carving, and local arts and crafts in its gift shop..

The U.S. Fish and Wildlife headquarters in Bethel maintains a display illustrating activities available within the Yukon Delta National Wildlife Refuge. This 20-million-acre area is a premier wildlife habitat where visitors can view swans, geese, ducks, and other shore and water birds, as well as moose, caribou, brown bear, black bear, and wolves. Offshore, Nunivak Island supports herds of introduced musk oxen and reindeer.

Fishing, hunting, and backcountry recreation are excellent in the Yukon-Kuskokwim Delta area. Visitor facilities are limited in local villages, but residents are accommodating. Local guide services provide air transportation to areas of the wildlife refuge. The service is available from Bethel, Aniak, St. Mary's, and most other communities within the region. This area is ideal for a visitor who wishes to avoid tourist crowds and enjoys the slower pace of the local culture.